高江涛教授：团队负责人，博士生导师，福建省“闽江学者”。长期从事天然产物方面的研究。早年在美国密西西比大学药学院及国家天然产物中心深造，师从著名的天然产物专家Stephen Cutler 和 Mark Hamann 教授，于2010年获得博士学位后，在美国伊利诺伊大学香槟分校的基因组生物研究所进行博士后研究，师从著名的化学生物学专家Wilfred van der Donk 教授（美国艺术与科学学院院士，美国霍华德休斯医学研究所研究员），同时在合成生物学家赵惠民实验室从事过天然产物的合成生物学研究。主要从事后基因组时代微生物天然产物抗生素的开发，包括微生物基因组的分子信息学分析、微生物天然产物的分离纯化、结构解析、天然产物的全合成及结构修饰、生物合成途径的探索以及蛋白酶的催化机制研究。研究成果获得了国际同行的高度认同，以第一作者或者共同通讯作者在Chemical Reviews，Angewandte Chemie International Edition，Chemical Communications等国际顶级杂志发表11篇SCI论文，其中单篇影响因子超过10的文章2篇。目前实验室有在读博士3名，硕士9名。

已经发表期刊论文：

 (1) Chuchu Guo, Dr. Dhanaraju Mandalapu, Xinjian Ji, Jiangtao Gao*, Qi Zhang*. Chemistry and biology of teixobactin. Chemistry-A European Journal 2017, 23:1-18 (IF=5.317)

 (2) Hao Cheng, Qian zhu, Wenjuan Ji, Xinjian Ji, Leixia Chu, Chuchu Guo, Wei Ding, Jiangtao Gao*, Qi Zhang*. Reactivity of the nitrogen-centered tryptophanyl radical in the catalysis by the radical SAM enzyme Nosl. Chemical Communications 2017, 53: 344-347 (IF=6.319)

 (3) Kou-San Ju, Jiangtao Gao, James R. Doroghazi, Kwo-Kwang A. Wang, Christopher J. Thibodeaux, Steven Li, Emily Metzger, John Fudala, Joleen Su, Jun Kai Zhang, Jaeheon Lee, Joel P. Cioni, Bradley S. Evans, Ryuichi Hirota, David P. Labed, Wilfred A. van der Donka, William W. Metcalf^*. Discovery of phosphonic acid natural products by mining the genomes of 10,000 actinomycetes. Proceedings of National Academy of Sciences, 2015, 112(39): 12175-12180(IF=9.809)

 (4) Jiangtao Gao#, Kou-San Ju, Xiaomin Yu, Juan E. Velásquez, Subha Mukherjee, Jaeheon Lee, Changming Zhao, Bradley S. Evans, James R. Doroghazi, William W. Metcalf*, Wilfred A. van der Donk*. Use of a Phosphonate Methyltransferase in the Identification of the Fosfazinomycin Biosynthetic Gene Cluster. Angewandte Chemie International Edition, 2014, 126: 1358-1361 (IF=11.994)

 (5) Jiangtao Gao#, Mohamed M. Radwan, Francisco León, Olivia Reed Dale, Afeef S. Husni, Yunshan Wu, Shari Lupien, Xiaoning Wang, Susan P. Manly, Robert A. Hill, Frank M. Dugan, Horace G. Cutler, Stephen J. Cutler*. Neocosmospora sp.-Derived Resorcylic Acid Lactones with in Vitro Binding Affinity for Human Opioid and Cannabinoid Receptors. Journal of Natural Products, 2013, 76: 824-828 (IF=3.281)

 (6) Francisco Leόn,Jiangtao Gao,Olivia Reed Dale,Yunshan Wu, Eman Habib, Afeef S. Husni, Robert A. Hill, Stephen J. Cutler^*. Secondary Metabolites from Eupenicillium parvum and Their in Vitro Binding Affinity for Human Opioid and Cannabinoid Receptors. Planta Medica, 2013, 79(18): 1756-1761(IF=2.342)

 (7) Bradley Evans, Changming Zhao, Jiangtao Gao, Courtney Evans, Kou-San Ju, James Doroghazi, Wilfred van der Donk, Neil Kelleher, William Metcalf^*. Discovery of the antibiotic phosacetamycin via a new mass spectrometry-based method for phosphonic acid detection. ACS chemical Biology, 2013, 8: 908-913 (IF=4.995)

 (8) Jiangtao Gao#, Mohamed M. Radwan, Francisco Leόn, Shari Lupien, Melissa R. Jacob, Babu L. Tekwani, Shabana I. Khan, Xiaoning Wang, Robert A. Hill, Frank M. Dugan, Horace G. Cutler, Stephen J. Cutler*. Antimicrobial and Antiprotozal Activity of Benzyl Derivatives from the Fungus Eurotium repens. Medicinal Chemistry Research, 2012, 21: 3080-3086 (IF=1.277)

 (9) William W. Metcalf, Benjamin M. Griffin, Robert M. Cicchillo, Jiangtao Gao, Sarath Chandra Janga, Heather A. Cooke,Benjamin T. Circello, Bradley S. Evans,Willm Martens-Habbena, David A. Stahl, Wilfred A. van der Donk^*. Synthesis of methylphosphonic acid by marine microbes: a source for methane in the aerobic ocean. Science, 2012, 337: 1104-1107 (IF=31.027)

 (10) Jiangtao Gao#, Mark T. Hamann*. Chemistry and biology of kahalalides. Chemical Reviews, 2011, 111: 3208-3215 (IF=47.928)

 (11) Jiangtao Gao#, Mohamed M. Radwan, Francisco Leόn, Olivia Reed Dale, Corey Anthony Gemelli, Susan Pinckney Manley, Shari Lupien, Xiaoning Wang, Robert A. Hill, Frank M. Dugan, Horace G. Cutler, Stephen J. Cutler*. Benzyl Derivatives with in Vitro Binding Affinity for Human Opioid Receptors and Cannabinoid Receptors from the Fungus Eurotium repens. Journal of Natural Products, 2011, 74: 1636-1639 (IF=3.281)

团队成员：

廖丽娟，讲师，博士，毕业于韩国首尔大学药学院，从事天然产物的分离、纯化、结构鉴定及相关活性研究。

楼轶，助理研究员，博士，毕业于华中农业大学，从事植物病害生物防治以及微生物次级代谢产物生物合成途径研究。