汪世华，男，博士，二级教授，博导，英国威廉希尔公司科技处处长，福建省病原真菌与真菌毒素重点实验室主任，福建省重点学科和一流学科“生物学”一级学科博士点学科带头人，英国威廉希尔公司学术委员会秘书长，曾任福建省科协挂职副主席。
现为国家百千万人才工程人选、国家有突出贡献中青年专家，享受国务院政府特殊津贴专家，全国模范教师，教育部新世纪优秀人才，教育部高等学校生物技术生物工程类专业教学指导委员会委员，国家一流专业建设点（生物技术）负责人，获教育部霍英东青年教师奖，福建省优秀博士论文指导教师，福建省杰出青年基金，获福建省五一劳动奖章，福建青年五四奖章。
主要从事农业微生物和微生物毒素方面的研究，中国菌物学会常务理事、真菌毒素专业委员会主任，中国微生物学会理事、分析微生物专业委员会副主任，福建省生物工程学会理事长。
一、主持的科研项目
国家重点研发计划课题（2023YFA0915103），2023-2028，主持
国家重点研发计划课题（2019YFC0312602），2020-2022，主持
国家重点研发计划课题（2023YFD1600503），2023-2027，子课题主持
国家重点研发计划课题（2017YFD0200601），2017-2020，子课题主持
国家自然科学基金面上项目（32370205），2024-2027，主持
国家自然科学基金面上项目（31972214），2020-2023，主持
国家自然科学基金面上项目（31772105），2018-2021，主持
国家自然科学基金面上项目（31172297），2012-2012，主持
国家自然科学基金面上项目（30771400），2008-2010，主持
福建省促进海洋与渔业产业高质量发展专项资金项目（FJHYF-L-2023-21），2023-2025，主持
二、科技获奖
1)福建省科技进步奖二等奖，排名第一，2022
2)福建省技术发明奖二等奖，排名第一，2014
3)福建省自然科学奖二等奖，排名第一，2010
4)福建省优秀学术论文一等奖，排名第一，2020
5)福建省青年科技奖，个人，2011
6)福建省运盛青年科技奖，个人，2011
三、专著及主编教材
1)汪世华等编著．黄曲霉与黄曲霉毒素．科学出版社，2017;
2)汪世华等编著．《抗体技术》（第二版）．科学出版社，2018;
3)汪世华主编．《蛋白质工程》第二版．科学出版社，2017;
4)汪世华主编．《分子生物学》．高等教育出版社，2011
四、综合荣誉
国家百千万人才工程人才人选、有突出贡献中青年专家，2019
享受国务院政府特殊津贴专家，2014
教育部新世纪优秀人才支持计划，2010；
全国模范教师，2014
教育部霍英东青年教师奖三等奖，2012
福建省政协第十一届、十二届委员会委员，2012
《Frontiers in Food Microbiology》编委（2013-）、专刊共同主编
《Toxins》编委（2021－）、专刊主编
五、学术论文代表作
1) Zhuo Zhu, Mingkun Yang, Guang Yang, Bei Zhang, Xiaohong Cao, Jun Yuan, Feng Ge*, Shihua Wang*. PP2C phosphatases Ptc1 and Ptc2 dephosphorylate PGK1 to regulate autophagy and aflatoxin synthesis in the pathogenic fungus Aspergillus flavus. mBio, 2023, 14(5): e0097723. DOI: 10.1128/mbio.00977-23.
2) Meifang Wen, Huahui Lan, Ruilin Sun, Xuan Chen, Xin Zhang, Zhuo Zhu, Can Tan, Jun Yuan, Shihua Wang*. Histone deacetylase SirE regulates development, DNA damage response and aflatoxin production in Aspergillus flavus. Environmental Microbiology, 2022, 24 (11): 5596–5610. doi: 10.1111/1462-2920.16198.
3) Sen Wang#, Yu Wang#, Yinghang Liu#, Lin Liu, Jinyu Li, Kunlong Yang, Mengxin Liu, Wanlin Zeng, Ling Qin, Ranxun Lin, Xinyi Nie, Longguang Jiang,Shihua Wang*. The Regulatory Role of theAspergillus flavus Core Retromer Complex in Aflatoxin Metabolism. Journal of Biological Chemistry, 2022, 298 (7): 102120. DOI: https://doi.org/10.1016/j.jbc.2022.102120.
4) Xuan Chen#, Lianghuan Wu#, Huahui Lan#, Ruilin Sun, Meifang Wen, Danrui Ruan, Mengjuan Zhang, Shihua Wang*. Histone acetyltransferases MystA and MystB contribute to morphogenesis and aflatoxin biosynthesis by regulating acetylation in fungus Aspergillus flavus. Environmental Microbiology, 2022, 24(3): 1340-1361. DOI:10.1111/1462-2920.15856.
5) Zhenhong Zhuanga,#, Xiaohua Pana,c,#, Mengjuan Zhanga, Yaju Liua, Chuanzhong Huangb, Yu Lia, Ling Haoa, Shihua Wanga,*. Set2 family regulates mycotoxin metabolism and virulence via H3K36 methylation in pathogenic fungus Aspergillus flavus. Virulence, 2022, 13 (1): 1358-1378. doi: 10.1080/21505594.2022.2101218.
6) Sumei Ling#, Mingke Dong#, Yang Xu, Aidi Xu, Jingjing Lin, Ming Lin, Qiang Zhao, Shihua Wang*. Development of sensitive and portable immunosensors based on signal amplification probes for monitoring the mercury(II) ions. Biosensors and Bioelectronics, 2022, 27: 114676. https://doi.org/10.1016/j.bios.2022.114676.
7) Zhuo Zhu+, Gengli Ma+ Mingkun Yang, Can Tan, Guang Yang, Sen Wang, Na Li, Feng Ge, Shihua Wang*. Ras subfamily GTPasesregulate development, aflatoxin biosynthesis and pathogenicity in the fungus Aspergillus flavus. Environmental Microbiology,2021, 23(9): 5334-5348.
8) Yu Wang#, Sen Wang#, Xinyi Nie, Kunlong Yang, Peng Xu, Xiuna Wang, Mengxin Liu, Yongshuai Yang, Zhuo Chen, Shihua Wang*. Molecular and structural basis of nucleoside diphosphate kinase–mediated regulation of spore and sclerotia development in the fungus Aspergillus flavus. Journal of Biological Chemistry, 2019, 294(33): 12415-12431.
9) Guang Yang#, Yuewei Yue#, SilinRen#, Mingkun Yang#, Yi Zhang, Xiaohong Cao, Yinchun Wang, Jia Zhang, Feng Ge, Shihua Wang*. Lysine acetylationcontributes todevelopment, aflatoxin biosynthesis and pathogenicity in Aspergillus flavus. Environmental Microbiology, 2019, 21 (12): 4792-4807.
10) Zhuo Zhu#, Mingkun Yang#, Youhuang Bai#, Feng Ge, Shihua Wang*. Antioxidant Related Catalase CTA1 Regulates Development, Aflatoxin Biosynthesis and Virulence in Pathogenic Fungus Aspergillus flavus. Environmental Microbiology, 2020,22 (7): 2792-2810.
11) Xuan Chen#, Lianghuan Wu#, Huahui Lan#, Ruilin Sun, Meifang Wen, Danrui Ruan, Mengjuan Zhang, Shihua Wang*. Histone acetyltransferases MystA and MystB contribute to morphogenesis and aflatoxin biosynthesis by regulating acetylation in fungus Aspergillus flavus. Environmental Microbiology, 2021, 11. DOI:10.1111/1462-2920.15856.
12) Mingkun Yang, Zhuo Zhu, Youhuang Bai, Zhenhong Zhuang, Feng Ge, Mingzhu Li, Shihua Wang*. A novel phosphoinositide kinaseFab1 regulates biosynthesis of pathogenic aflatoxin in Aspergillus flavus. Virulence, 2021, 12 (1): 96-113.
13) Can Tan†, Jili Deng†, Feng Zhang, Zhuo Zhu, Lijuan Yan, Mengjuan Zhang, Jun Yuan, Shihua Wang*. CWI pathway participated in vegetative growth and pathogenicity through a downstream effector AflRlm1 in Aspergillus flavus. iScience, 2021, 24 (10): 103159.
14) Silin Ren#,Mingkun Yang#,Yuewei Yue#, Feng Ge,Yu Li, Xiaodong Guo, Jia Zhang, Feng Zhang, Xinyi Nie, Shihua Wang*. Lysine SuccinylationContributes to Aflatoxin Production and Pathogenicity in Aspergillus flavus. Molecular &cellular proteomics, 2018, 17 (3): 457-471.
15) Guang Yang, Xiaohong Cao, Genli Ma, Ling Qin, Yuanzhen Wu, Jian Lin, Peng Ye, Jun Yuan, Shihua Wang*. MAPK pathway-related tyrosine phosphatases regulate development, secondary metabolism and pathogenicity in fungus Aspergillus flavus. Environmental Microbiology, 2020, 22 (12): 5232-5247.
16) Mingkun Yang, Zhuo Zhu, Zhenhong Zhuang, Youhuang Bai, Shihua Wang*, Feng Ge*. Proteogenomic characterization of the pathogenic fungus Aspergillus flavus reveals novel genes involved in aflatoxin production. Molecular and Cellular Proteomics, 2021, 20: 100013.
17) Rongzhi Wang#, Juncheng Wang#, Haimei Liu, Yehong Gao, Qiang Zhao, Sumei Ling, Shihua Wang*. Sensitive immunoassays based on specific monoclonal IgG for determination of bovine lactoferrin in cow milk samples. Food Chemistry,2021, 338: 127820.
18) Peiyuan Cai, Rongzhi Wang, Sumei Ling, Shihua Wang*. A high sensitive platinum-modified colloidal gold immunoassay for tenuazonic acid detection based on monoclonal IgG. Food Chemistry, 2021, 360: 130021.
19) Sumei Ling#, Xiulan Li#, Qiang Zhao, Rongzhi Wang, Tao Tan, Shihua Wang*. Preparation of monoclonal antibody against penicillic acid (PA) and its application in the immunological detection. Food Chemistry, 2020, 319: 126505. https://doi.org/10.1016/j.foodchem.2020.126505.
20) Sumei Ling#, Qiang Zhao#, Muhammad Naeem Iqbal#, Mingke Dong, Xiulan Li, Ming Lin, Rongzhi Wang, Feiya Lei, Caizhen He, Shihua Wang*. Development of immunoassay methods based on monoclonal antibody and its application in the determination of Cadmium ion. Journal of Hazardous Materials, 2021, 411：124992.
21) Feng Zhang#,Luhua Huang#,Jili Deng#,Can Tan,LongpoGeng, Yun Liao, Jun Yuan, Shihua Wang*. A cell wall integrity-related MAP kinase kinasekinase AflBck1 is required for growth and virulence in fungus Aspergillus flavus. Molecular Plant-Microbe Interactions, 2020, 33 (4): 680-692.
22) Huahui Lan, Lianghuan Wu, Ruilin Sun, Nancy P Keller, Kunlong Yang, Liuqing Ye, Shuibin He, Feng Zhang, Shihua Wang*. The HosA histone deacetylase associates with Sin3 to control aflatoxins biosynthesis through direct regulation of aflatoxin cluster genes. Molecular Plant-Microbe Interactions, 2019, 32 (9): 1210-1228.
23) Sumei Ling, Qing-Ai Chen, Yuming Zhang, Rongzhi Wang, Ni Jin, Jie Pang, Shihua Wang*. Development of ELISA and Colloidal Gold Immunoassay for Tetrodotoxin Detetcion Based on the Monoclonal Antibody. Biosensors and Bioelectronics, 2015, 71, 256-260.
24) Rongzhi Wang, Linmao Zeng, Hang Yang, Yanfang Zhong, Juncheng Wang, Sumei Ling, Abdullah farhan Saeed, Jun Yuan, Shihua Wang*. Detection of Okadaic Acid (OA) using ELISA and Colloidal gold immunoassay based on monoclonal antibody. Journal of Hazardous Materials, 2017, 339: 154-100.
25) Jing Zhang, Xi Zhang, Guidi Yang, Jinghua Chen*,Shihua Wang*.A signal-on fluorescent aptasensor based on Tb3+ and structure switchingaptamer for label-free detection of Ochratoxin A in wheat. Biosensors and Bioelectronics, 2013，41: 704-709.
26) Bin Wang, Xiaoyun Han, Youhuang Bai, MengguangQiu, Feng Zhang, Zhenhong Zhuang, Jun Yuan, Xinyi Nie, Shihua Wang*. Effects of nitrogen metabolism on growth and aflatoxin biosynthesis in Aspergillus flavus. Journal of Hazardous Materials, 2016, 324: 691–700.
27) Zhenhong Zhuang*, Yaling Huang, Yanling Yang, Shihua Wang*. Identification of AFB1-interacting proteins and interactions between RPSA and AFB1. Journal of Hazardous Materials, 2016,301: 297-303.
28) Jinghua Chen, Xi Zhang, Shuxian Cai, Dongzhi Wu, Mei Chen, Shihua Wang*, Jing Zhang*, A Fluorescent Aptasensor based on DNA Scaffolded Silver-Nanocluster for Ochratoxin A Detection, Biosensors and Bioelectronics,2014，57：226-231
29) Kunlong Yang#, Yinghang Liu#, Sen Wang, Lianghuan Wu, Rui Xie, Huahui Lan, Opemipo Esther Fasoyin, Yu Wang, Shihua Wang*. The cyclase-associated protein Cap with multi-domain contributes to mycotoxin biosynthesis and fungal virulence in Aspergillus flavus. Journal of Agricultural and Food Chemistry, 2019, 67 (15): 4200-4213.
30) Rongzhi Wang, Xiaosong Gu,Zhenghong Zhuang, Yanfang Zhong, Hang Yang,Shihua Wang*.Screening and molecular evolution of a single chain variable fragment antibody (scFv) against Citreoviridin toxin.Journal of Agricultural and Food Chemistry, 2016, 64: 7640-7648.
31) Xinyi Nie, Song Yu, MengguangQiu, Xiuna Wang, Yu Wang, Youhuang Bai, Feng Zhang, Shihua Wang*. Aspergillus flavus SUMO Contributes to the Fungal Virulence and Toxin Attributes. Journal of Agricultural and Food Chemistry, 2016, 64: 6772-6782.
32) Weijuan Yang, Jinghua Chen, Guonan Chen, Shihua Wang*, Fengfu Fu*. The early diagnosis and fast detection of blast fungus, Magnaporthegrisea, in rice plant by using its chitinase as biochemical marker and a rice cDNA encoding mannose-binding lectin as recognition probe. Biosensors and Bioelectronics, 2013, 41: 820-826.
33) Rongzhi Wang, Shuangshuang Xiang, Yonghui Zhang, Qiuyu Chen, Yanfang Zhong, Shihua Wang*. Development of functional antibody using green fluorescence protein (GFP) frame as template. Applied and Environmental Microbiology, 2014, 80 (14) : 4126-4137.
34) Rongzhi Wang, Sui Fang, Dinglong Wu, JunweiLian, Jue Fan, Yanfeng Zhang, Shihua Wang*, Wenxiong Lin*. Screening of a ScFv Antibody that can neutralize effectively the cytotoxicity of Vibrio parahaemolytucsTLH. Applied and Environmental Microbiology, 2012, 78 (14): 4967-4975.
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